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Jessix schreef:

Ja steeds meer.. Nu zijn er ook onderzoeken die op maagzweren wijzen terwijl men vroeger juist luzerne aanprees om dat tegen te gaan. Zo blijf je altijd aan het puzzelen met voer...

Jessix schreef:

Nee, volwassen paarden. Ik heb nooit iets gelezen over onderzoek bij veulens.

Efficacy of sainfoin (Onobrychis viciifolia) pellets against multi resistant Haemonchus contortus and interaction with oral ivermectin: Implications for on-farm control schreef:

Abstract
The worldwide spread of resistance to anthelmintic (AH) drugs in gastrointestinal nematodes (GINs) imposes to explore alternative solutions. Amongst those, the possible use of tannin-containing nutraceuticals appears as a relevant option to replace (or decrease the frequency of) chemical-based treatments. Our objectives were to test the AH efficacy of sainfoin pellets against a multiresistant strain of Haemonchus contortus in experimentally infected lambs and to examine possible interaction between ivermectin (IVM) and condensed tannins (CT)-rich ressource.

In vivo study was performed with twenty-four lambs were inoculated (Day 0) with multiresistant H. contortus infective larvae. On D21 Post-Infection, the lambs were assigned to two dietary treatments (sainfoin vs lucerne control pellets). On D39, half of the animals per group received 0.25 ml/kg of an oral ivermectin treatment. On D47, animals were slaughtered to count worms. The consumption of sainfoin was associated with higher packed cell volume (PCV) values (P < 0.05) and reduced faecal egg counts (FECs) (P < 0.05). For the experimental feeding period, FECs were overall reduced by 50% in the sainfoin group. The diet did not have significant effect on the worm number but sainfoin significantly reduced female fertility. Decrease in plasma IVM concentrations was observed in the sainfoin-fed animals and was associated with a decrease of IVM efficiency when compared with the control group. Incubating tannin in vitro with ivermectin and rumen fluid showed a blocking of ivermectin by the tannins. This suggests that tannins lower the IVM intestinal absorption compromising thereby drug plasma bioavailability and efficacy.

Tannin-containing nutraceuticals alter the biology of multiresistant nematodes, thus representing an option for their sustainable control. In vivo and in vitro interactions between nutraceuticals and chemicals impose caution when both tannin-rich diet and drug-based treatments are combined. Further studies are required to clarify the mechanisms that support such interactions.

Auteurs: Elodie Gaudin, Margaux Simon, Jessica Quijada, François Schelcher, Jean-François Sutra, Anne Lespine, Hervé Hoste

Inclusion of sainfoin (Onobrychis viciifolia) silage in dairy cow rations affects nutrient digestibility, nitrogen utilization, energy balance, and methane emissions schreef:

[...] These results suggest that inclusion of sainfoin silage in dairy cow rations reduces CH4 per kilogram of DM intake and nutrient digestibility. Moreover, sainfoin silage improves milk production and seems to redirect metabolism toward body protein accretion at the expense of body fat.
Auteurs: N.T. Huyen, O. Desrues, S.J.J. Alferink, T. Zandstra, M.W.A. Verstegen, W.H. Hendriks, W.F. Pellikaan

Consequences of the regular distribution of sainfoin hay on gastrointestinal parasitism with nematodes and milk production in dairy goats schreef:

The objectives of the current study were to examine the potential effects of distribution of sainfoin hay on nematode parasitism in a producing herd and to measure the consequences on milk production. The survey was performed in an experimental herd of 120-dairy-goat farm during a whole 9-month grazing season. Every month, 60 goats received indoors on average 1.36 kg of sainfoin hay for 10 days whereas the 60 remaining goats were used as controls, thus receiving the same amount of lucerne hay at the same time. The nutritional values of both hays were comparable except that concentrations of condensed tannins was higher in sainfoin than in lucerne hay, i.e. 2.52% versus 0.7% of diet DM. Intakes of the two types of hay were recorded along with each period. Individual faecal and blood samples were performed monthly to compare parasitological and pathophysiological parameters in the two groups. Milk yield, fat and protein contents were measured fortnightly. A higher consumption of hay was repeatedly recorded in the sainfoin versus the control group. Irrespective to dietary treatment, nematode egg excretions were low during the whole season. Meanwhile, egg output was significantly lowest in the sainfoin group, but the composition in nematode genera was similar among the two groups. Based on a semi quantitative index for assessment of faecal consistency, a lower faecal dry matter content was also found in goats from the sainfoin group. The two animal groups exhibited similar milk yield, fat and protein contents. The differences in egg excretion between the two groups might be due to higher intake of hay in the barn thus to low consumption of grass, a source of parasite infection, or to the effect of some secondary compounds, like tannins. Whatever the mechanism involved, our results suggest that a regular distribution of sainfoin hay to dairy goats might be associated with a reduction in parasitism with gastrointestinal nematodes, without negative consequences on milk production.
Auteurs: H. Hoste, L. Gaillard, Y. Le Frileux